Putting on the brakes: Bacterial impediment of wound healing

Putting on the brakes: Bacterial impediment of wound healing

The epithelium provides a crucial barrier to infection, and its integrity requires efficient wound healing. Bacterial cells and secretomes from a subset of tested species of bacteria inhibited human and porcine corneal epithelial cell migration in vitro and ex vivo. Secretomes from 95% of Serratia marcescens, 71% of Pseudomonas aeruginosa, 29% of Staphylococcus aureus strains, and other bacteri...

Putting the brakes on chondrosarcoma

Primary cartilaginous tumors often arise from endochondral ossification, range from benign endochondroma and osteochondroma to malignant chondrosarcoma, and are notoriously resistant to chemotherapy or radiation. This urges development of novel therapeutic approaches particularly in chondrosarcoma, which is a terminal disease in more than 90% of unresectable cases [1]. Now research of Zhou and ...

Putting the Brakes on Fear

The extinction of fear is believed to involve inhibitory processes in the amygdala. In this issue of Neuron, Trouche et al. (2013) show that basal amygdala neurons activated by fear conditioning are silenced by local inhibitory interneurons after extinction.

Putting the brakes on cylindromatosis?

In patients with familial cylindromatosis, or “turban tumors,” numerous benign skin adnexal tumors develop, principally on the head and neck (Fig. 1). This rare disorder is caused by a mutation of the CYLD gene and has a variable penetrance. Thanks to three recent studies 2-4 and, in particular, to the work of Brummelkamp and colleagues, 2 we now have a more accurate conception of the disease p...

Putting the brakes on drive-through deliveries.